CINCINNATI UNIV OF

$345,561

from Department of Health and Human Services · National Institutes of Health

MECHANISTIC UNDERPINNINGS OF PRPS DEFICIENCY DISORDERS - PROJECT SUMMARY THIS PROPOSAL SEEKS TO UNDERSTAND THE MECHANISTIC BASIS FOR DISEASES CAUSED BY LOSS-OF-FUNCTION MISSENSE MUTATIONS IN THE GENE ENCODING PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1 (PRPS1). THE PRPS ENZYME IS CONSERVED FROM BACTERIA TO HUMANS AND IT CATALYZES AN ESSENTIAL CHOKEPOINT REACTION IN CELLULAR METABOLISM THAT ROUTES...
Description as recorded in the federal award record (cut at 400 characters).

Award ID: R01GM164373
Award type: PROJECT GRANT (B)
First obligated: Jul 30, 2026
Period starts: Aug 1, 2026
Place of performance: Hamilton County, Ohio 45206
Assistance listing: 93.859 BIOMEDICAL RESEARCH AND RESEARCH TRAINING
Amount means: Federal obligation for this grant, as of our last read Oct 13, 2026.

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